The Effect of Gossypol, Gossypolone and Apogossypol on the Lipids of Male Rat Serum and Seminal Fluid

The neutral and polar lipids of serum and seminal fluid of male rats were investigated under .t~e effect of gossypol acetic acid, apogossypol and gossypolone. The. total phospholipids. and. the neutral serum l.Ipids showed positive and negative significant correlation with the duratiOn .of gossypol acetic acid treatment, :espe~tively. At. the same time, free fatty acids content significantly increased w1th apogossypol and gos~ypol acetic ac.Id. In. serumal fluids, the total lipid fraction showed insignificant variation in spite of the correlatiOn betwee~. tnglycendes ~nd sterylester content. In control animals, triglycerides and sterylester contents shov:ed po.sJtive and n~gat1ve correlation, respectively. Only sterylester showed a negative significant correlatiOn w1t·h· the duratiOn of apogossypol treatment. This result may be related to the negative effect of apogossypol on fertility. The effect of gossypol acetic acid, apogossypol and gossypolone on the total phospholipids constituents of male rat seru~ a~d seminal fluid were studied. Phosphatidyl inositol was significantly decreased under the effect of gossypol. acet~c aCid and gossypolone in the serum, and negatively significant correlated w.ith t~e. duration of gossypol acetic acid and gossypolone treatment in the seminal fluid. The results indicate that mfe~Ihty dose of ~ossypol .and ~ossypolo.ne exhibit some metabolic effect by elevation of lipolysis and perhaps depressiOn of phospatidyl mosltol bwsynthes1s.